Isaiah 64:10

“Thy holy cities are a wilderness, &c.] Meaning either Zion, the city of David, and Jerusalem; the one called the upper, the other the lower city; now uninhabited, and a mere wilderness: or else the other cities of Judea, in which were formerly synagogues for religious service, and in which dwelt many godly families where the worship of God was kept up; but now a desert, at least quite devoid of true religion and godliness. Zion is a wilderness, Jerusalem a desolation; which are either explanative of the holy cities in the preceding clauses, or are mentioned as distinct from them; the account proceeding from the lesser to the metropolitan cities, which fared no better than they did, but…”

“holy cities--No city but Jerusalem is called "the holy city" (Isa 48:2; Isa 52:1); the plural, therefore, refers to the upper and the lower parts of the same city Jerusalem [VITRINGA]; or all Judea was holy to God, so its cities were deemed "holy" [MAURER]. But the parallelism favors VITRINGA. Zion and Jerusalem (the one city) answering to "holy cities."”

“Thy holy cities are a wilderness - It is to be remembered that this is supposed to be spoken near the close of the exile in Babylon. In accordance with the usual custom in this book, Isaiah throws himself forward by prophetic anticipation into that future period, and describes the scene as if it were passing before his eyes (see the Introduction, Section 7). He uses language such as the exiles would use; he puts arguments into their mouths which it would be proper for them to use; he describes the feelings which they would then have. The phrase, ‘thy holy cities,’ may either mean the cities of the holy land - which belonged to God, and were ‘holy,’ as they pertained to his people; or it may…”

“64:10 holy cities: All the cities of Judah were considered holy to God. However, the Temple in the host city of Jerusalem was the most holy place.”

“Isa 1:7; Kg2 25:9; Ch2 36:19-21; Psa 79:1-7; Lam 1:1-4, Lam 2:4-8, Lam 5:18; Dan 9:26, Dan 9:27, Dan 12:7; Mic 3:12; Luk 21:21, Luk 21:24; Rev 11:1, Rev 11:2 Isaiah 64:11”