Isaiah 39:7

“And of thy sons that shall issue from thee, which thou shalt beget, shall they take away, &c.] Manasseh his immediate son was taken and carried to Babylon, though afterwards released; nor does it appear that he was made a eunuch or an officer there; this had its fulfilment in Jeconiah and his children, and in others that were of the seed royal, as Daniel, Hananiah, Mishael, and Azariah, to whom the Jewish commentators apply this; this is expressed in different words, signifying much the same, to affect the mind of Hezekiah the more: and they shall be eunuchs in the palace of the king of Babylon; or “chamberlains”; and who very often were castrated for that purpose, though it does not…”

“sons . . . from thee--The sons which Hezekiah (as JOSEPHUS tells us) wished to have (see on Isa 28:3, on "wept sore") will be among the foremost in suffering. eunuchs--fulfilled (Dan 1:2-3, Dan 1:7).”

“And of that sons - Thy posterity (see the note at Matthew 1:1). That shall issue from thee - Of the royal family. The captivity at Babylon occurred more than a hundred years after this, and of course those who were carried there were somewhat remote descendants of Hezekiah. And they shall be eunuchs - The word used here (סריסים sâriysiym) denotes properly and strictly eunuchs, or such persons as were accustomed to attend on the harems of Oriental monarchs Esther 2:3, Esther 2:14-15. These persons were also employed often in various offices of the court Esther 1:10, Esther 1:12, Esther 1:15, and hence, the word often means a minister of court, a court-officer, though not literally an eunuch…”

“of thy sons: Kg2 24:12, Kg2 25:6, Kg2 25:7; Ch2 33:11, Ch2 36:10, Ch2 36:20; Jer 39:7; Eze 17:12-20 they shall be: Fulfilled, Dan 1:2-7 Isaiah 39:8”