Revelation 16:1

“And I heard a great voice out of the temple, etc.] The church, which in the preceding chapter is said to be opened; this was either the voice of God, whose temple the church is, and where he dwells, and who, has power over these plagues, (<661609>Revelation 16:9) and who, when he is about to bring judgments on the earth, is said to roar out of Zion, (<661616>Revelation 16:16) or of Christ, who is always in the midst of his church and people, and whose voice is as the voice of many waters; (see <661615> Revelation 16:15) or it may be of one of the four living creatures, the ministers of the word, in and by whom Christ often speaks; and the rather, since one of these gave the seven angels the…”

“THE SEVEN VIALS AND THE CONSEQUENT PLAGUES. (Rev. 16:1-21) a great voice--namely, God's. These seven vials (the detailed expansion of the vintage, Rev 14:18-20) being called "the last," must belong to the period just when the term of the beast's power has expired (whence reference is made in them all to the worshippers of the beast as the objects of the judgments), close to the end or coming of the Son of man. The first four are distinguished from the last three, just as in the case of the seven seals and the seven trumpets. The first four are more general, affecting the earth, the sea, springs, and the sun, not merely a portion of these natural bodies, as in the case of the trumpets, but…”

“And I heard a great voice out of the temple - A loud voice out of the temple as seen in heaven (notes on Revelation 11:19), and that came, therefore, from the very presence of God. Saying to the seven angels - That had the seven vials of wrath. See the notes on Revelation 15:1, Revelation 15:7. Go your ways - Your respective ways, to the fulfillment of the task assigned to each. And pour out the vials of the wrath of God - Empty those vials; cause to come upon the earth the plagues indicated by their contents. The order in which this was to be done is not intimated. It seems to be supposed that that would be understood by each. Upon the earth - The particular part of the earth is not here…”

“Pour out the seven phials - The epistles to the seven churches are divided into three and four: the seven seals, and so the trumpets and phials, into four and three. The trumpets gradually, and in a long tract of time, overthrow the kingdom of the world: the phials destroy chiefly the beast and his followers, with a swift and impetuous force. The four first affect the earth, the sea, the rivers, the sun; the rest fall elsewhere, and are much more terrible. Revelation 16:2”

“16:1-21 These seven bowls filled with God’s wrath represent the final judgments on the world; with the seventh bowl, “It is finished!” is shouted from God’s throne (16:17; cp. John 19:30). 16:1 The mighty voice probably belongs to God (also in 6:6; 9:13; 16:17; 18:4; 19:5; see Isa 66:6).”

“I heard: Rev 14:15, Rev 14:18, Rev 15:5-8 the seven: Rev 15:1, Rev 15:6 and pour: Rev 16:2-12, Rev 16:17, Rev 14:9-11, Rev 15:7; Sa1 15:3, Sa1 15:18; Eze 9:5-8, Eze 10:2; Mat 13:41, Mat 13:42 Revelation 16:2”