Mark 3:21

“When his friends heard of it, etc..] Not his spiritual friends, his disciples and followers, that believed in him; but his kinsmen, as the Syriac and Ethiopic versions render the words, who were so according to the flesh; when they heard where he was, and what a crowd was about him, so that he could not so much as take the necessaries of life for his refreshment and support, they went out to lay hold on him: either out of their houses at Capernaum, or they went forth from Nazareth, where they dwelt, to Capernaum, to take him from this house, where he was thronged and pressed, along with them; where he might have some refreshment without being incommoded, and take some rest, which seemed very…”

“When his friends - Greek, “they who were of him.” Not the apostles, but his relatives, his friends, who were in the place of his nativity. Heard of it - Heard of his conduct: his preaching; his appointing the apostles; his drawing such a multitude to his preaching. This shows that by “his friends” were not meant the apostles, but his neighbors and others who “heard” of his conduct. They went out to lay hold on him - To take him away from the multitude, and to remove him to his home, that he might be treated as a maniac, so that, by absence from the “causes” of excitement, he might be restored to his right mind. They said - That is, common report said; or his friends and relatives said, for…”

“His relations - His mother and his brethren, Mar 3:31. But it was some time before they could come near him. Mark 3:22”

“3:21 He’s out of his mind: Mark does not explain whether the attempt by Jesus’ family to seize him was motivated by sincere but misguided concern, or by hostility. Jesus’ brothers and sisters were not among his followers until after his resurrection (3:31-35; John 7:3-5; 1 Cor 15:7 mentions James, the brother of Jesus, who became a leader of the Jerusalem church, Acts 15:13-21).”

“when: Some render, "And they who were with him (in the house, Mar 3:19), hearing (the noise) went out to restrain (αυτον, i.e., οχλον \[Strong's G3793\], the multitude), for they said, It (the mob) is mad." This, however, is contrary to all the versions; and appears an unnatural construction. friends: or, kinsmen, Mar 3:31; Joh 7:3-10 He is: Kg2 9:11; Jer 29:26; Hos 9:7; Joh 10:20; Act 26:24; Co2 5:13 Mark 3:22”