Isaiah 51:18

“There is none to guide her among all the sons whom she hath brought forth, &c.] Still alluding to drunken persons staggering in the streets, that can scarcely stand on their feet, and do not know their way, and yet have none to hold them up and guide them, not even of their friends and relations: neither is there any that taketh her by the hand of all the sons that she hath brought up; to hold her up from falling, of which there is danger by reeling to and fro, through the intoxicating liquor; and this, either for want of sons, these being dead, or through want of filial affection in them. This was true of Jerusalem, literally understood, at the time of her last destruction by the Romans,…”

“Following up the image in Isa 51:17, intoxicated and confused by the cup of God's anger, she has none to guide her in her helpless state; she has not yet awakened out of the sleep caused by that draught. This cannot apply to the Babylonish captivity; for in it they had Ezekiel and Daniel, Ezra and Nehemiah, as "guides," and soon awoke out of that sleep; but it applies to the Jews now, and will be still more applicable in their coming oppression by Antichrist.”

“There is none to guide her - The image here is taken from the condition of one who is under the influence of an intoxicating draught, and who needs some one to sustain and guide him. The idea is, than among all the inhabitants of Jerusalem in the time of the calamity, there was none who could restore to order the agitated and distracted affairs of the nation. All its wisdom was destroyed; its counsels perplexed; its power overcome. All the sons whom she hath brought forth - All the inhabitants of Jerusalem. return to 'Top of Page'”

“None to guide - When thou wast drunk with this cup, and not able to go. Isaiah 51:19”

“none: Isa 3:4-8, Isa 49:21; Psa 88:18, Psa 142:4; Mat 9:36, Mat 15:14 that taketh: Isa 41:13, Isa 45:1; Job 8:20 \*marg. Jer 31:32; Mar 8:23; Act 9:8, Act 13:11; Heb 8:9 Isaiah 51:19”