Genesis 3:15

“And I will put enmity between thee and the woman, etc.] Between whom there had been so much familiarity, not only while they had the preceding discourse together, but before; for it is conjectured by some f222, that she took a particular liking to that creature, and was delighted with it, and laid it perhaps in her bosom, adorned her neck with its windings, or made it a bracelet for her arms; and being a peculiar favourite, the devil made choice of it as his instrument to deceive her; but now being beguiled hereby, she conceived an antipathy against it, and which is become natural between the serpent and man; man abhors the sight of a serpent, and the serpent the sight of man; and the…”

“thy seed--not only evil spirits, but wicked men. seed of the woman--the Messiah, or His Church [CALVIN, HENGSTENBERG]. I will put enmity between thee and the woman--God can only be said to do so by leaving "the serpent and his seed to the influence of their own corruption; and by those measures which, pursued for the salvation of men, fill Satan and his angels with envy and rage." thou shalt bruise his heel--The serpent wounds the heel that crushes him; and so Satan would be permitted to afflict the humanity of Christ and bring suffering and persecution on His people. it shall bruise thy head--The serpent's poison is lodged in its head; and a bruise on that part is fatal. Thus, fatal shall…”

“- XVI. The Judgment 15. שׁוּף shûp “bruise, wound.” τηρεῖν (=τερεῖν?) tērein ἐκτρίβειν ektribein Job 9:17, καταπατεῖν katapatein Psalms 139:11, συντρίβειν suntribein Romans 16:20. 16. תשׁוּקה teshûqâh “desire, inclination.” αποστροφή apostrofee, ἐπιστροφή epistrophē Song of Solomon 7:11. 20. חוּה chavâh Eve, “the living, life, life-place, or village.” This passage contains the examination of the transgressors, Genesis 3:8-13; the sentence pronounced upon each, Genesis 3:14-19; and certain particulars following thereupon, Genesis 3:20-21. Genesis 3:8-9 The voice, we conceive, is the thunder of the approach of God and his call to Adam. The hiding is another token of the…”

“And I will put enmity between thee and the woman - The inferior creatures being made for man, it was a curse upon any of them to be turned against man, and man against them. And this is part of the serpent's curse. A perpetual reproach is fastened upon him. Under the cover of the serpent he is here sentenced to be, (1.) Degraded and accursed of God. It is supposed, pride was the sin that turned angels into devils, which is here justly punished by a great variety of mortifications couched under the mean circumstances of a serpent, crawling on his belly, and licking the dust. (2.) Detested and abhorred of all mankind: even those that are really seduced into his interest, yet profess a hatred…”

“3:15 hostility: The prophet Isaiah envisions the day when the Messiah’s kingdom will restore all of creation to a harmonious state like the Garden of Eden before humans sinned (see Isa 11:8). • her offspring (literally her seed): This collective noun can refer to a single descendant or many. The ancient Near Eastern concept of corporate solidarity (e.g., “you and your descendants,” Gen 28:14) is also behind this description of the ongoing hostility that would exist between humans and snakes. The pattern is set using singular terms (He . . . you). Christian interpreters have traditionally understood this verse as a prophecy of Christ, the seed of Abraham and the culmination of the woman’s…”

“enmity: Num 21:6, Num 21:7; Amo 9:3; Mar 16:18; Luk 10:19; Act 28:3-6; Rom 3:13 thy seed: Mat 3:7, Mat 12:34, Mat 13:38, Mat 23:33; Joh 8:44; Act 13:10; Jo1 3:8, Jo1 3:10 her seed: Psa 132:11; Isa 7:14; Jer 31:22; Mic 5:3; Mat 1:23, Mat 1:25; Luk 1:31-35, Luk 1:76; Gal 4:4 it shall: Rom 16:20; Eph 4:8; Col 2:15; Heb 2:14, Heb 2:15; Jo1 3:8, Jo1 5:5; Rev 12:7, Rev 12:8, Rev 12:17; Rev 20:1-3, Rev 20:10 thou: Gen 49:17; Isa 53:3, Isa 53:4, Isa 53:12; Dan 9:26; Mat 4:1-10; Luk 22:39-44, Luk 22:53; Joh 12:31-33, Joh 14:30, Joh 14:31; Heb 2:18, Heb 5:7; Rev 2:10, Rev 12:9-13, Rev 13:7, Rev 15:1-6; Rev 20:7, Rev 20:8 Genesis 3:16”