Revelation 6:10

“And they cried with a loud voice, etc.] With great ardour and fervency, being very pressing and importunate; and which shows that they were awake, and not asleep, and that the soul does not sleep with the body in the grave, or is after the death of that in a state of insensibility and inactivity, as some imagine: saying, how long, O Lord, holy and true; the person they address is either the Lamb in the midst of the throne, with whom they were, and under the shelter of whom they were safe and happy; or God the Father, who sat upon the throne, whom they call “holy”, because being so in his nature, and as appears in all his works, he could not but hate, and so revenge the evil that was done to…”

“How long--Greek, "Until when?" As in the parable the woman (symbol of the Church) cries day and night to the unjust judge for justice against her adversary who is always oppressing her (compare below, Rev 12:10); so the elect (not only on earth, but under Christ's covering, and in His presence in Paradise) cry day and night to God, who will assuredly, in His own time, avenge His and their cause, "though He bear long with them." These passages need not be restricted to some particular martyrdoms, but have been, and are receiving, and shall receive partial fulfilments, until their last exhaustive fulfilment before Christ's coming. So as to the other events foretold here. The glory even of…”

“And when he had opened the fifth seal - notes at Revelation 5:1; Revelation 6:1. I saw under the altar - The four living creatures are no longer heard as in the opening of the first four seals. No reason is given for the change in the manner of the representation; and none can be assigned, unless it be, that having represented each one of the four living creatures in their turn as calling attention to the remarkable events about to occur, there seemed to be no necessity or propriety in introducing them again. In itself considered, it cannot be supposed that they would be any less interested in the events about to be disclosed than they were in those which preceded. This seal pertains to…”

“And they cried - This cry did not begin now, but under the first Roman persecution. The Romans themselves had already avenged the martyrs slain by the Jews on that whole nation. How long - They knew their blood would be avenged; but not immediately, as is now shown them. O Lord - The Greek word properly signifies the master of a family: it is therefore beautifully used by these, who are peculiarly of the household of God. Thou Holy One and true - Both the holiness and truth of God require him to execute judgment and vengeance. Dost thou not judge and avenge our blood? - There is no impure affection in heaven: therefore, this desire of theirs is pure and suitable to the will of God. The…”

“6:10 The martyrs shouted to the Sovereign Lord because they trusted in his power to redress their grievances. • how long: Is God slow to act? Will justice be done? God does act decisively (see 6:12-14); his wrath (6:16-17) must be understood in terms of justice, fairness, and righteousness (see Exod 34:5-7; Neh 9:17; Pss 103:8; 145:8; Joel 2:13; Jon 4:2; Rom 2:6-11). • avenge our blood: This cry for God’s justice follows the pattern of imprecatory (vengeance) psalms (see Pss 6:3; 74:10; 79:5; 80:4; 137:1-9). It also reflects the covenant curses of Deut 28:53-57; 32:35 (quoted in Rom 12:19).”

“they cried: Gen 4:10; Psa 9:12; Luk 18:7, Luk 18:8; Heb 12:24 How: Psa 13:1, Psa 35:17, Psa 74:9, Psa 74:10, Psa 94:3, Psa 94:4; Dan 8:13, Dan 12:6; Zac 1:12 holy: Rev 3:7, Rev 15:3, Rev 15:4 dost: Rev 11:18, Rev 16:5-7, Rev 18:20, Rev 18:24, Rev 19:2; Deu 32:36-43; Jdg 16:28; Sa1 24:12; Psa 58:10, Psa 58:11; Isa 61:2, Isa 63:1-6; Luk 21:22; Rom 12:19; Th2 1:6-8 avenge: This seal seems a prediction of the terrible persecution of the church under Dioclesian and Maximian, from ad 270 to 304, which lasted longer, and was far more bloody, than any or all by which it was preceded, whence it was called "the era of the martyrs. Revelation 6:11”