Revelation 16:19

“And the great city was divided into three parts, etc.] By which is meant not Christendom, distinguished into Protestants, Papists, and neutrals, which has been long the case; nor the city of Jerusalem, as inhabited by Christians, Jews, and Turks; nor the city of Rome itself, the seat of the beast, which will have suffered under the fifth vial; but the whole Romish jurisdiction, which is the great city, that reigns over the kings of the earth, as it will now be; though some think the Turkish empire is meant, which they suppose was only afflicted under the preceding vial, but will now be divided into three parts, and afterwards into six, (<263901>Ezekiel 39:1,2) and so come to ruin; and others…”

“the great city--the capital and seat of the apostate Church, spiritual Babylon (of which Rome is the representative, if one literal city be meant). The city in Rev 11:8 (see on Rev 11:8), is probably distinct, namely, Jerusalem under Antichrist (the beast, who is distinct from the harlot or apostate Church). In Rev 11:13 only a tenth of Jerusalem falls whereas here the city (Babylon) "became (Greek) into three parts" by the earthquake. cities of the nations--other great cities in league with spiritual Babylon. great . . . came in remembrance--Greek, "Babylon the great was remembered" (Rev 18:5). It is now that the last call to escape from Babylon is given to God's people in her (Rev 18:4).…”

“And the great city was divided into three parts - The city of Babylon; or the mighty power that was represented by Babylon. See the notes on Revelation 14:8. The division mentioned here in three parts was manifestly with reference to its destruction - either that one part was smitten and the others remained for a time, or that one form of destruction came on one part, and another on the others. In Revelation 11:13 it is said, speaking of “the great city spiritually called Sodom and Egypt” - representing Rome, that “the tenth part of the city fell, and in the earthquake were slain of men seven thousand” (see the notes on that place); here it is said that the whole city, in the calamities that…”

“And the great city - Namely, Jerusalem, here opposed to the heathen cities in general, and in particular to Rome. And the cities of the nations fell - Were utterly overthrown. And Babylon was remembered before God - He did not forget the vengeance which was due to her, though the execution of it was delayed. Revelation 16:20”

“the great: Rev 14:8, Rev 17:18, Rev 18:2, Rev 18:10, Rev 18:16-19, Rev 18:21 great: Rev 17:5; Dan 4:30 in: Rev 14:8-10, Rev 18:5; Isa 49:26, Isa 51:17-23; Jer 25:15, Jer 25:16, Jer 25:26 Revelation 16:20”