Psalms 69:21

“Instead of such, his enemies increase his pain by giving him most distasteful food and drink. The Psalmist may have thus described by figure what Christ found in reality (compare Joh 19:29-30).”

“They gave me also - My enemies; all persons around me. No one would show me even so much kindness as to give me food when I was hungry, or drink when I was thirsty. They utterly forsook me; they left me to die unpitied. Nay, they did more than this. When I was perishing with hunger, they not only refused to give me wholesome food, but they mocked my sufferings by giving me a bitter and poisonous herb for food, and vinegar for my drink. Gall for my meat - For my food. Or, they gave me this “instead” of wholesome food. The word here rendered “gall” - ראשׁ rô'sh - is the same “in form” which is commonly rendered “head,” and occurs in this sense very often in the Scriptures. It is also used to…”

“Gall - Instead of giving me that comfort which my condition required, they added to my afflictions. Vinegar - These things were metaphorically fulfilled in David, but properly in Christ, the description of whose sufferings was principally intended here by the Holy Ghost. Psalms 69:22”

“69:21 sour wine for my thirst: This description applies to Jesus’ suffering (Matt 27:34, 48; Luke 23:36; John 19:28-29).”

“gall for my meat: Bochart, from a comparison of this passage with Joh 19:29, thinks that rosh is the same herb as the evangelist calls υσσωπος, hyssop; a species of which, growing in Judea, he proves from Isaac ben Orman, an Arabian writer, to be so bitter as not to be eatable. Theophylact expressly tells us, that the hyssop was added ως δηλητεριωδος, as being deleterious, or poisonous, and Nonnus, in his paraphrase, says, Ωρεγεν υσσωπωκεκερασμενον οξος ολεθρου "One gave the deadly acid mixed with hyssop." Jer 8:14, Jer 9:15, Jer 23:15; Mat 27:34, Mat 27:48 vinegar: Mar 15:23, Mar 15:36; Luk 23:36; Joh 19:29, Joh 19:30 Psalms 69:22”