Matthew 12:48

“But he answered and said unto him that told him, etc.] Of his mother and brethren being without doors, desiring, and waiting to speak to him, Who is my mother? and who are my brethren? These questions are put, not as if he himself was ignorant who were his mother or his brethren; or as suggesting as if he had none; or as denying that these were in such a relation to him; or as casting any slight upon them; or as intending to teach men disrespect to parents and kindred, according to the flesh; but as displeased with the man, or men, for interrupting him in his work; and to let them know, that the business of his heavenly Father was preferred by him to any his natural relations could have with…”

“See also Mark 3:31-35; Luke 8:19-21. His brethren - There has been some difference of opinion about the persons who are referred to here, some supposing that they were children of Mary his mother, others that they were the children of Mary, the wife of Cleophas or Alpheus, his “cousins,” and called “brethren” according to the customs of the Jews. The natural and obvious meaning is, however, that they were the children of Mary his mother. See also Mark 6:3. To this opinion, moreover, there can be no valid objection. Matthew 12:48 Who is my mother? ... - There was no want of affection or respect in Jesus toward his mother, as is proved by his whole life. See especially Luke 2:51, and John…”

“And he answering, said - Our Lord's knowing why they came, sufficiently justifies his seeming disregard of them. Matthew 12:49”

“12:48-50 Those who are true members in Jesus’ family do the will of the Father, as expressed in the commands of Jesus (see 7:21). Obedience does not earn entrance into this family, but one cannot be considered a member if he or she is not obedient (see 3:15; 5:17-48; 6:10, 12; 7:13-27; 21:31).”

“Who is: Mat 10:37; Deu 33:9; Mar 3:32, Mar 3:33; Luk 2:49, Luk 2:52; Joh 2:3, Joh 2:4; Co2 5:16 Matthew 12:49”