Isaiah 66:21

“And I will also take of them for priests, &c.] That is, of the Gentiles, the brethren brought as an offering to the Lord; and therefore must respect Gospel times, when the Aaronic priesthood would be changed and cease, which admitted not of Gentiles, nor any of any other tribe in Israel, but the tribe of Levi; nor is this to be understood of the spiritual priesthood common to all believers, (<600205>1 Peter 2:5,9 <660106>Revelation 1:6 5:10) since of those converted Gentiles brought, not all, but only some of them, would be taken for priests; and therefore can only be interpreted of the ministers of the word, who, in Old Testament language, are called priests, though never in the New…”

“of them--the Gentiles. priests . . . Levites--for spiritual worship: enjoying the direct access to God which was formerly enjoyed by the ministers of the temple alone (Pe1 2:9; Rev 1:6).”

“And I will also take of them for priests - I will give to them an honorable place in my public service; that is, I will make them ministers of religion as if they were priests and Levites. This cannot be taken literally - because the priests and Levites among the Jews were determined by law, and by regular genealogical descent, and there was no provision for substituting any in their place. But it must mean that under the condition of things described here, those who should be brought from the distant pagan world would perform the same offices in the service of God which had been performed formerly by the priests and Levites that is, they would be ministers of religion. The services of God…”

“For priests - God will find among the converted Gentiles those who though they are not of the tribe of Levi, yet shall do the true work of priests and Levites. Isaiah 66:22”

“66:21 That some of the Gentiles would serve as priests and Levites signifies the removal of God’s distinction between Hebrews and Gentiles (see 56:7; see also Gal 6:15; Eph 4:11-13).”

“Isa 61:6; Exo 19:6; Jer 13:18-22; Pe1 2:5, Pe1 2:9; Rev 1:6, Rev 5:10, Rev 20:6 Isaiah 66:22”

“The latter, having been incorporated into the priestly congregation of Jehovah ( Isa 61:6), are not even excluded from the priestly and Levitical service of the sanctuary. "And I will also add some of them to the priests, to the Levites, saith Jehovah." Hitzig and Knobel suppose mēhem to refer to the Israelites thus brought home. But in this case something would be promised, which needed no promise at all, since the right of the native cohen and Levites to take part in the priesthood and temple service was by no means neutralized by their sojourn in a foreign land. And even if the meaning were that Jehovah would take those who were brought home for priests and Levites, without regard to…”