Isaiah 59:3

“For your hands are defiled with blood, and your fingers with iniquity, &c.] From a general charge, the prophet proceeds to a particular enumeration of sins they were guilty of; and idolatry not being mentioned, as Jerom observes, shows that the prophecy belongs to other times than Isaiah’s, when that sin greatly prevailed. He begins the account with the sin of shedding blood; the blood of innocents, as the Targum; designing either the sin of murder, now frequently committed in Christian nations; or wars between Christian princes, by means of which much blood is shed; or persecutions of Christian brethren, by casting them into prisons, which have issued in their death; and at least want of…”

“(Isa 1:15; Rom 3:13-15). hands . . . fingers--Not merely the "hands" perpetrate deeds of grosser enormity ("blood"), but the "fingers" commit more minute acts of "iniquity." lips . . . tongue--The lips "speak" openly "lies," the tongue "mutters" malicious insinuations ("perverseness"; perverse misrepresentations of others) (Jer 6:28; Jer 9:4).”

“For your hands are defiled with blood - The prophet proceeds here more particularly to specify the sins of which they were guilty; and in order to show the extent and depth of their depravity, he specifies the various members of the body - the hands, the fingers, the lips, the tongue, the feet as the agents by which people commit iniquity. See a similar argument on the subject of depravity in Romans 3:13-15, where a part of the description which the prophet here gives is quoted by Paul, and applied to the Jews in his own time. The phrase ‘your hands are defiled with blood,’ means with the blood of the innocent; that is, they were guilty of murder, oppression, and cruelty. See a similar…”

“Perverseness - Perverse words are such as are contrary to God's word. Words every way contrary to God's will. Isaiah 59:4”

“your hands: Isa 1:15, Isa 1:21; Jer 2:30, Jer 2:34, Jer 22:17; Eze 7:23, Eze 9:9, Eze 22:2, Eze 35:6; Hos 4:2; Mic 3:10-12, Mic 7:2; Mat 27:4 your lips: Jer 7:8, Jer 9:3-6; Eze 13:8; Hos 7:3, Hos 7:13; Mic 6:12; Ti1 4:2 Isaiah 59:4”

“The sins of Israel are sins in words and deeds. "For your hands are defiled with blood, and your fingers with iniquity; your lips speak lies, your tongue murmurs wickedness." The verb גּאל, to spot (see Isa 63:3), is a later softening down of גּעל (e.g., Sa2 1:21); and in the place of the niphal נגאל ( Zep 3:1), we have here, as in Lam 4:14, the double passive form נגאל, compounded of niphal and pual. The post-biblical nithpal, compounded of the niphal and the hithpael, is a mixed form of the same kind, though we also meet with it in a few biblical passages ( Deu 21:8; Pro 27:15; Eze 23:48). The verb hâgâh (lxx μελετᾶ) combines the two meanings of "thought" (meditation or reflection), and…”