Isaiah 43:28

“Therefore I have profaned the princes of the sanctuary, &c.] Or will do it; the past tense for the future, common in prophetic writings; these are not Moses and Aaron, or the kings, but the priests of the temple, who had the care and government of things there, and therefore called “princes”; these, when this prophecy was fulfilled, were treated as common persons, and divested of their office, and laid aside; their priesthood and the honour of it were taken from them; sacrifices were abolished, and the law concerning them; this was more especially true when Jerusalem was destroyed, the temple burnt, and the daily sacrifice made to cease, by the Romans: and have given Jacob to the curse, and…”

“profaned the princes-- (Psa 89:39; Lam 2:2, Lam 2:6-7). I have esteemed, or treated, them as persons not sacred. I have left them to suffer the same treatment as the common people, stripped of their holy office and in captivity. princes of the sanctuary--"governors of" it (Ch1 24:5); directing its holy services; priests. curse--Hebrew, cherim, a "solemn anathema," or "excommunication." reproaches-- (Psa 123:3-4). Next: Isaiah Chapter 44”

“Therefore I have profaned - The princes of the sanctuary, that is, the priests, were by their office regarded as sacred, or set apart to the service of God. To depose them from that office, to subject them to punishment, and to send them into captivity, was, therefore, regarded as profaning them. They were stripped of their office, and robes, and honors, and reduced to the same condition, and compelled to meet with the same treatment, as the common people. The sense is, that he had made them common (for so the word חלל châlal is used in Exodus 31:14; Exodus 19:22; Leviticus 19:8; Leviticus 21:9; Malachi 1:12; Malachi 2:2); he did not regard their office; he used them all alike. The princes…”

“Therefore - I have exposed them to contempt and destruction. Princes - The highest and best of your priests. Curse - To utter destruction, to which persons or things accursed were devoted. Next: Isaiah Chapter 44”

“I have: Isa 47:6; Sa2 1:21; Psa 89:39; Lam 2:2, Lam 2:6, Lam 2:7, Lam 4:20 princes: or, holy princes, Psa 82:6, Psa 82:7 and have: Isa 42:24, Isa 42:25, Isa 65:15; Deu 28:15-20, Deu 29:21-28; Psa 79:4; Jer 24:9; Dan 9:14; Zac 8:13; Luk 21:21-24; Th1 2:16 Next: Isaiah Chapter 44”

“Consequently the all-holy One was obliged to do what had taken place. "Then I profaned holy princes, and gave up Jacob to the curse, and Israel to blasphemies." ואחלל might be an imperfect, like ואכל, "I ate," in Isa 44:19, and ואבּיט, "I looked," in Isa 63:5; but ואתּנה by the side of it shows that the pointing sprang out of the future interpretation contained in the Targum; so that as the latter is to be rejected, we must substitute ואחלל, ואתּנה (Ges. 49, 2). The "holy princes" (sârē qōdesh) are the hierarchs, as in Ch1 24:5, the supreme spiritual rulers as distinguished from the temporal rulers. The profanation referred to was the fact that they were ruthlessly hurried off into a…”