Exodus 4:24

“And it came to pass by the way, in the inn, etc.] As Moses and his family were travelling in their way to Egypt, at an inn where they stopped for the refreshment of themselves and cattle, or in order to lodge all night: so it was, that the Lord met him, and sought to kill him; not the uncircumcised son of Moses, as some think, but Moses himself, who had neglected the circumcision of his son; that from the context, and the fact of Zipporah, after related, seems to be the reason of the divine displeasure, and not his bringing his family with him, supposed to be an hinderance of him in his work, nor of his staying too long at the inn, and not hastening his journey, which are the reasons given…”

“inn--Hebrew, "a halting place for the night." the Lord met him, and sought to kill him--that is, he was either overwhelmed with mental distress or overtaken by a sudden and dangerous malady. The narrative is obscure, but the meaning seems to be, that, led during his illness to a strict self-examination, he was deeply pained and grieved at the thought of having, to please his wife, postponed or neglected the circumcision of one of his sons, probably the younger. To dishonor that sign and seal of the covenant was criminal in any Hebrew, peculiarly so in one destined to be the leader and deliverer of the Hebrews; and he seems to have felt his sickness as a merited chastisement for his sinful…”

“In the inn - Or “resting place.” See Genesis 42:27 note. Met him, and sought to kill him - Moses was attacked by a sudden and dangerous illness, which he knew was inflicted by God. The word “sought to kill” implies that the sickness, whatever might be its nature, was one which threatened death had it not been averted by a timely act. Zipporah believed that the illness of Moses was due to his having neglected the duty of an Israelite, and to his not having circumcised his own son; the delay was probably owing to her own not unnatural repugnance to a rite, which though practiced by the Egyptians, was not adopted generally in the East, even by the descendants of Abraham and Keturah. Moses…”

“It seems the sin of Moses, was neglecting to circumcise his son, which perhaps was the effect of his being unequally yoked with a Midianite, who was too indulgent of her child, and Moses so of her. The Lord met him, and, probably, by a sword in an angel's hand, sought to kill him - This was a great change. Very lately God was conversing with him as a friend, and now coming forth against him as an enemy. In this case of necessity Zipporah herself circumcised the child without delay; whether with passionate words, expressing the dislike of the ordinance itself, or at least the administration of it to so young a child. Exodus 4:26”

“4:24-26 This incident is shrouded in mystery. That Zipporah responded immediately and circumcised her son suggests that she and Moses had discussed the possibility of doing so previously and had decided it was not necessary. Why would having an uncircumcised son lead to God’s intent to kill the rescuer he had carefully prepared and called? Perhaps if Moses had arrived in Egypt claiming to represent the God of the Israelites’ ancestors and yet had not done the one thing God had commanded of his followers to this point (Gen 17:10), then the people would have been less inclined to follow God in a radically exclusive way.”

“the inn: Gen 42:27; The account in this and the two following verses, although rather obscure, seems to imply, that on their way to the land of Egypt, an angel appeared to Moses, and sought to kill his son, on account of his father's non-observance of the Lord's positive command to Abraham, that every man child of the Jewish nation, or born in his house in servitude, should be circumcised on the eighth day; and the Zipporah, at the command of Moses, immediately fulfilled the injunction, and thus averted the wrath of God, denounced against the disobedient: "The uncircumcised man child, whose flesh of his foreskin is not circumcised, that soul shall be cut off from his people." Gen 17:14 the…”