Daniel 7:21

“I beheld, and the same horn made war with the saints, etc.] The same little horn before described; not Antiochus Epiphanes, who made war with the Jews, as many think; or the Roman Caesars, that persecuted the church of Christ, as others; nor Titus Vespasian, who fought against Israel, as Saadiah; but antichrist, or the pope of Rome; and this refers to the wars of the popes with the Waldenses, which began in the year 1160, and continued long, and with the two witnesses at the close of their testimony, (<661107>Revelation 11:7 13:7), this Daniel had a view of in vision; not while he was inquiring of the angel, but before, though not mentioned till now; and was a reason he was so very…”

“made war with the saints--persecuted the Church (Rev 11:7; Rev 13:7). prevailed--but not ultimately. The limit is marked by "until" (Dan 7:22). The little horn continues, without intermission, to persecute up to Christ's second advent (Rev 17:12, Rev 17:14; Rev 19:19-20).”

“I beheld, and the same horn made war with the saints - I continued to look on this until I saw war made by this horn with the people of God. This circumstance, also, is not referred to in the first description, and the order of time in the description would seem to imply that the war with the saints would be at a considerable period after the first appearance of the horn, or would be only when it had grown to its great size and power. This “war” might refer to open hostilities, carried on in the usual manner of war; or to persecution, or to any invasion of the rights and privileges of others. As it is a “war with the saints,” it would be most natural to refer it to persecution. And prevailed…”

“7:21 The object of the little horn’s hatred and arrogance was God’s holy people. In this, the little horn was like Pharaoh and Haman (see Exod 1:22; Esth 3:8-9; cp. Dan 11:36-40).”

“Dan 8:12, Dan 8:24, Dan 11:31, Dan 12:7; Rev 11:7-9, Rev 12:3, Rev 12:4, Rev 13:5-7, Rev 13:8-18, Rev 17:6, Rev 17:14, Rev 19:19 Daniel 7:22”