Daniel 11:21

“And in his estate shall stand up a vile person, etc.] Upon his basis or stand, in the same place where Seleucus Philopator stood, succeeded Antiochus Epiphanes his brother, called “vile”, being a very immoral man, given to drunkenness, lasciviousness, uncleanness, and unnatural lusts, and a violent persecutor of the church of God. The word signifies “despicable”f544; he was a vile person, and justly condemned for his vices, and also for that mean and ignoble life he had lived at Rome, having been an hostage there for eleven or twelve years; and though the other hostages were changed at three years’ end, yet he remained; which shows what little account he was of even with his father; and was…”

“vile--Antiochus called Epiphanes, that is, "the illustrious," for vindicating the claims of the royal line against Heliodorus, was nicknamed, by a play of sounds, Epimanes, that is, "the madman," for his mad freaks beneath the dignity of a king. He would carouse with the lowest of the people, bathe with them in the public baths, and foolishly jest and throw stones at passers-by [POLYBIUS, 26.10]. Hence, as also for his crafty supplanting of Demetrius, the rightful heir, from the throne, he is termed "vile." they shall not give . . . kingdom: but . . . by flatteries--The nation shall not, by a public act, confer the kingdom on him, but he shall obtain it by artifice, "flattering" Eumenes and…”

“And in his estate - In his place. See the notes at Daniel 11:7, Daniel 11:20. Shall stand up a vile person - There shall succeed to the throne. The reference here is to Antiochus Epiphanes, who reigned from 175 b.c. to 163 b.c. The epithet “vile” here given him was one which his subsequent history showed was eminently appropriate to him in all respects, as a man and as a prince. The Hebrew word rendered “vile” - נבזה nı̂bezeh - properly means one despised or held in contempt, Isaiah 49:7; Psalms 22:6 (7). The meaning here is, that he was one who deserved to be despised, and who would be held in contempt - a man of a low, base, contemptible character. Vulgate, “despectus;” Greek ἐξουδενώθη…”

“A vile person - Antiochus, called Epiphanes by his flatterers, but the people of God accounted him infamous, base, and treacherous. They - Neither peers nor people, nor was he the heir, but his nephew; but he crept in by flatteries. Daniel 11:22”

“11:21-39 The next to come to power was Antiochus IV Epiphanes (175–163 BC). He is also the “small horn” of Dan 8:9-14, 23-26. He is described vividly in 1 Maccabees 1:7–6:16; 2 Maccabees 1:1–10:5; 4 Maccabees 4:15–18:5. Antiochus was despicable both because he had usurped the kingship and for his deeds as king. He was not in line for royal succession but usurped the throne from his brother’s son.”

“estate: or, place, Dan 11:7, Dan 11:20 shall stand: Dan 7:8, Dan 8:9, Dan 8:23, Dan 8:25 a vile person: Antiochus Epiphanes, called also Epimanes or madman, for his despicable conduct. Sa1 3:13; Psa 12:8, Psa 15:4; Isa 32:5; Nah 1:14 by flatteries: Dan 11:32, Dan 11:34; Judg. 9:1-20; Sa2 15:2-6; Psa 55:21 Daniel 11:22”

“The further Unveiling of the Future In this section we have ( Dan 11:21) first the description of the prince who, in striving after supremacy, sues all the means that cunning and power can contrive, and in his enmity against the holy covenant knows no bounds. This description is divided into two parts - (1) Dan 11:21-25, and (2) vv. 36-12:3-which designate the two stadia of his proceedings. In the first part are described, (1) his gradual rising to power, Dan 11:21-24; (2) his war with the king of the south for the supremacy, Dan 11:25-27; (3) his rising up against the covenant people, even to the desecration of the sanctuary by the taking away of the daily sacrifice and the setting up of…”